Access the Country — and the World — From St. Louis

Located near the geographic and population centers of the U.S., Greater St. Louis sits within 500 miles of nearly one-third of the nation’s population. The region’s highly developed logistics infrastructure offers reliable and efficient connections — global businesses in St. Louis can easily manufacture and distribute products throughout the nation and the world.

Our robust trade, transportation and warehousing sector comprises more than 6,000 establishments and 110,000 employees. Multinational brands like Hershey, Unilever, and Procter & Gamble house regional distribution facilities, each exceeding one million square feet. Notable wholesalers and distribution headquarters include Graybar, UniGroup, and World Wide Technology. Amazon has nine distribution centers of various types throughout the region, totaling 4 million square feet, and employs more than 7,000 workers.

The St. Louis region offers abundant flat land and extensive real estate suitable for distribution centers, including over 7,000 buildings with more than 300 million square feet of industrial space, as well as two large Foreign-Trade Zones with more than 10,000 acres of sites.


The region’s network of highways is robust, including five interstates (I-44, I-55, I-64, I-70, I-270) and the Avenue of the Saints running between St. Louis and Minneapolis-St. Paul. These roadways make St. Louis one of the most accessible cities in the nation, so it’s not surprising that more than 1,000 truck transportation businesses operate in Greater St. Louis, employing almost 15,000 workers.


St. Louis Lambert International Airportthe St. Louis region’s major airport, has 10 commercial air carriers with 70 non-stop destinations and features excellent access to I-70, a Foreign-Trade Zone and U.S. Customs on site, and 24-7 operations. Travelers can reach most major U.S. destinations within three hours or less, and a new, nonstop Lufthansa flight from St. Louis to Frankfurt, Germany, provides immediate access to Europe, Africa, and Asia. On the other side of the Mississippi River and adjacent to Scott Air Force Base in Illinois, MidAmerica Airport accommodates scheduled passenger, freight, and military flights. Other regional corporate airports include St. Louis Downtown Airport, St. Louis Regional Airport, and the Spirit of St. Louis Airport.


The Mississippi, Missouri and Illinois Rivers all meet in the St. Louis region, which is home to the nation’s third-largest inland water port by tonnage. The region offers the last lock and dam on the Mississippi River, as well as the northernmost port to remain ice-free year-round. Located in the City of St. Louis, the Port of Metropolitan St. Louis is served by all major barge lines and offers more than 100 docks and terminal facilities handling bulk commodities such as coal, grain, oil, and metals. America’s Central Port in Granite City, Illinois, includes the River’s Edge Business Park, which offers 840 acres for distribution, warehousing and manufacturing.


Greater St. Louis is the third largest rail hub in the U.S. and is served by Amtrak and six Class I Railroads (Burlington Northern Santa Fe, Canadian National Railway, CSX, Kansas City Southern, Norfolk Southern, and Union Pacific) that connect to four local and short line railroads. St. Louis is one of the few gateway cities where rail traffic can transfer between and originate from both the great eastern and western railroads.

How can we help?

The work of our business attraction team is confidential, complementary, and comprehensive. If you’re looking to consolidate, expand or move, we’re here to assist.