Our 15-county Region Spans Through Illinois and Missouri
Population numbers are derived from the U.S. Census Bureau’s County Population Totals: 2010-2019.
One of two easternmost counties in the region, Bond is dominated by agriculture, but the county also has successful resort and outdoor sport industries thanks to local Carlyle Lake.
Catch a ferry — a major mode of transportation for Calhoun — to reach parts of this small, picturesque county, located on a peninsula between the Mississippi and Illinois Rivers.
Located south of Bond County on the easternmost edge of the region, Clinton County has a larger, rural population that benefits from Carlyle Lake’s resort industry.
Jersey County, bordered on the west by the scenic Great River Road and the Mighty Mississippi, offers beautiful views and destinations for locals and tourists.
Drive north on Interstate 55 to reach Macoupin County, which sits halfway between St. Louis and Springfield, Illinois. Macoupin’s economy runs on agriculture.
One of the largest counties in the region, much of Madison’s population and employment is centered in the county seat, Edwardsville, and other larger cities like Alton, Collinsville and Granite City.
Monroe County sits at the southernmost end of the region and offers easy access to the City of St. Louis via Interstate 255 and the Jefferson Barracks Bridge.
A more populated county located just across the river from the City of St. Louis, St. Clair is home to both Scott Air Force Base and MidAmerica St. Louis Airport.
Here, manufacturing is the dominant industry, primarily in the city of Washington, but the small farms and wineries dotting the county’s picturesque landscape also contribute to the economy.
Located just south of St. Louis County and bordered on the east by the Mississippi River, county residents can easily access Memphis, St. Louis and Chicago via Interstate 55.
Beautiful Lincoln County is home to both a state park and a Mississippi River conservation area. Its growing population supports predominantly manufacturing and service industries.
One of the fastest growing counties in the country, St. Charles boasts a booming economy featuring a cross-section of industries.
The most densely populated and industrial county in the region, St. Louis City is a cultural, geographic and transportation nexus, home to both manufacturers and corporate headquarters.
The most populous county in the region, suburban St. Louis County is home to Clayton, the region’s county seat, which has abundant corporate offices and service businesses.
Primarily agricultural, Warren County shares a southern border with the Missouri River, can be accessed via Interstate 70, and offers picturesque land and conservation areas.
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